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KMID : 0378019790220080096
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New Medical Journal
1979 Volume.22 No. 8 p.96 ~ p.100
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Cadmium Concentration in Maternal Blood and Neonatal Cord Blood of Some Seoulities
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裵恩相/Bae, Eun Sang
金永煥/Kim, Young Whan
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Abstract
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Various trace metals have been implicated in human disease, for the most part after industrial exposure. Occasinally, these substances have contaminated life support system such as food, air, water and so on in large enough concentrations to produce acute or chronic illness.
In addition, the ingestion of toxic metals by pregnant women has been found to alter the development of the fetus. in the cases of Pb, Cd and Hg. This is probably the most important aspect of metal exposure of fertile women who are to be pregnant.
However, the mechanism is still unknown how the concentration of the metals in blood of fetus becomes to be diluted or concentrated in method of transferring from maternal blood through placental barrier.
Our concern has focused on 86 pregnant women admitted in some local clinics in Seoul for delivery care. From their blood of paired samples, concentrations of Cd were measured with atomic absorption spectrophotometer and the results were measured with atomic absorption spectrophotometer and the results were analysed as follows.
1. Mean blood concentraion for cadmium in maternal blood was 0.061±0.050pg/ml which was 1. 42 times higher than that in cord blood, 0. 043 ± 0. 04pg/ml showing significant statistical difference (p<0. 01).
2. Regarding frequency distributions for concentration ranges for cadmium, 23 samples out of 86 (26.7%) maternal blood belonged to 0.021-0.04pg/ml group whereas 30 out of 68 (34.9%) cord blood belonged to 0.00-0.002 pg/ml group. The distribution curves of the aboves revealed to be skewed and quite different from normal distribution curve.
3. Significant positive correlation was found between cadmium concentrations of maternal blood and cord showing regression line of
y=0.26 x+0.027 with r=0. 308 (pwhere y indicates concentration in cord blood,
x in maternal blood, and
r " correlation coefficient.
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